Genetic renegades: the B chromosomes of D. melanogaster

The Hanlon Lab studies how chromosomes move, form, and evolve. Our model system is the newly discovered B chromosomes in the fruit fly Drosophila melanogaster. B chromosomes are extra, nonessential chromosomes that have been found in hundreds of different plant and animal species and can promote their own segregation, sometimes to the detriment of their host. The Hanlon Lab applies a multitude of cellular, molecular, and genetic tools available in D. melanogaster to understand how B chromosomes rendezvous and segregate during cell division. We also investigate the intrinsic biology of these young B chromosomes, including their effects on life history traits, the frequency of their formation, and the flux of their heterochromatic repeat and transposable element composition over time.
Every year Stacey buys the lab ice cream and asks the lab to fill out a Lab Assessment Tool to provide feedback on her mentoring and the lab culture. Not many PIs do this, but more should! We are definitely very grateful to work with a PI who cares so much about their mentees.

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We had 2 new MCB graduate students recently join the lab! Welcome to the (A-quality) B-Team, Aale Agans and Grace Galarneau!

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Post of appreciation for our second rotation student @a.agans1227 !! Fun fact: for the award winning B Chromosome Express costume Aale wore an actual Amtrak conductors uniform! We love their commitment to the bit, and their curiosity about B chromosomes.

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Welcome to our first rotation student of the semester:Grace! 
Grace likes long walks on the beach and working with @ed_r00sell to figure out what our B chromosomes are made of using techniques like microscopy with fluorescent in situ hybridization (FISH) and ovary mitotic preps.

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The Hanlon Lab is putting the "B" in @biohaven! Two of our awesome graduate students, Shania (red vest) and Michelle (blue t-shirt), were awarded the Biohaven Pharmaceuticals Summer Fellowship for 2025. Thank you, @biohaven for supporting the next generation of awesome scientists!

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We love our grad students in the Hanlon lab. Here are the grad students currently uncovering clues about the Bs!

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Ed had the room Buzzing after sharing his plans to edit the B chromosome at RIPS

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Another un-B-lievable year in the Hanlon Lab! Thanks for all your hard work and making the lab a great place to B!

Clockwise, from bottom left: Michelle, Kaylah, Haneesh, Natalie, Robin, Stacey, Shania, Edward, Annette, Abby, and Suparna (not pictured: Paul).

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The Hanlon Lab had a B-witching time B-ing the crew from Inside Out 2 for Halloween! Such a creative bunch of scientists!

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Congratulations to Annette, an un-B-lievable undergrad in the lab, on her first poster presentation! She described her UConn SURF-sponsored research investigating how oocyte age affects B chromosome transmission. Great job!

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Haneesh J had an awesome rotation and helped put the "B" in Bioinformatics! Thanks for rotating through the Hanlon Lab!

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Great RIPS talk, Shania! Now everyone knows how these chromosomes came to 'B'...

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