Genetic renegades: the B chromosomes of D. melanogaster
The Hanlon Lab studies how chromosomes move, form, and evolve. Our model system is the newly discovered B chromosomes in the fruit fly Drosophila melanogaster. B chromosomes are extra, nonessential chromosomes that have been found in hundreds of different plant and animal species and can promote their own segregation, sometimes to the detriment of their host. The Hanlon Lab applies a multitude of cellular, molecular, and genetic tools available in D. melanogaster to understand how B chromosomes rendezvous and segregate during cell division. We also investigate the intrinsic biology of these young B chromosomes, including their effects on life history traits, the frequency of their formation, and the flux of their heterochromatic repeat and transposable element composition over time.
The Official Hanlon Lab Twitter!
- Welcome to the ‘B’ team, Shell!Shell Chen, Class of 2023, has decided to join the ‘B’ team! Her project will be examining the molecular interactions of the B chromosomes and their progenitor chromosome, Chromosome 4. We hope you’re glad to ‘B’ here!Posted on March 10, 2022
- Another Busy ‘B’: Michelle has decided to join the lab!The Hanlon Lab is the official new home of Mengjia Michelle Lin, currently a first-year Ph.D. student in the MCB Graduate Program. Her work will focus on the dynamics of B chromosomes during female meiosis. Welcome, Michelle!Posted on January 21, 2022
- A ‘B’ig welcome our final Fall rotons, Heather and Josette!The Hanlon Lab welcomes MCB predoctoral graduate students Heather and Josette for their last fall rotation! We hope you love the Bs as much as we do!Posted on December 1, 2021
- Great ‘B’-sentation by Paulo at the UConn Fall Frontiers ExhibitionHere’s Paulo Belato, ready to share his research as a McNair Scholar at the 2021 Fall Frontiers in Undergraduate Research exhibition. Way to go, Paulo!Posted on October 20, 2021
- Mengjia (Michelle) Lin begins her rotation in the Hanlon Lab – just in time for Halloween!Mengjia (Michelle) Lin is spending the second rotation cycle in the Hanlon Lab! Her project will be to examine how the B chromosomes segregate during a live female meiosis. Welcome to the lab Michelle, and we hope you have a ‘ghoul’ rotation during this spooky season!Posted on October 11, 2021